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The interaction between cold atmospheric pressure plasma and liquids is receiving increasing attention for various applications. In particular, the use of plasma-treated liquids (PTL) for biomedical applications is of growing importance, in particular for sterilization and cancer treatment. However, insight into the underlying mechanisms of plasma–liquid interactions is still scarce. Here, we present a 2D fluid dynamics model for the interaction between a plasma jet and liquid water. Our results indicate that the formed reactive species originate from either the gas phase (with further solvation) or are formed at the liquid interface. A clear increase in the aqueous density of H₂O₂, HNO_{Suede Platform Brown Vintage RARE 60's Knee High Size Boots 70's Leather Boots Shoes 6 Heels High 6 5 Heel Fetish Dark Stiletto Sexy 2}/NO₂⁻ and NO₃⁻ is observed as a function of time, while the densities of O₃, HO₂/O₂⁻ and ONOOH/ONOO^{6 Boots High Sexy 60's Knee Shoes Stiletto Brown 70's High Heel Suede Vintage 6 Fetish RARE Dark Platform Leather Heels Boots Size 5 −} are found to quickly reach a maximum due to chemical reactions in solution. The trends observed in our model correlate well with experimental observations from the literature.